Emeritus Professor M Saadeh Suleiman
PhD, DSc, FIACS, FESC, FRSB, FPhysiol
Expertise
Current positions
Emeritus Professor of Cardiac Physiology
Bristol Medical School (THS)
Contact
Press and media
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Research interests
Current Research Projects (basic science/translational/clinical):
- Role of cyclic AMP/PKA/Epac signalling in cardioprotection.
- Efficacy of propofol-supplemented cardioplegia on biomarkers of organ injury in patients having cardiac surgery using cardiopulmonary bypass: Propofol cardioplegia for myocardial protection randomised controlled trial: The Prompt2 Study.
- Cardiac remodelling post infarction during postnatal development.
- Effect of inflammation on cardiac remodelling post infarction.
- Hypertension induced cardiac remodelling.
- The cardio-protective efficacy of cardioplegic solution supplemented with Sildenafil in neonatal pig model of cardiopulmonary bypass and cardioplegic arrest.
Projects and supervisions
Research projects
Cardioprotection for cyanotic neonates
Principal Investigator
Role
Co-Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/09/2024 to 31/08/2029
Do measurements of circulating fibrosis markers change with disease progression in canine myxomatous mitral valve disease?
Principal Investigator
Role
Co-Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
17/05/2022 to 30/06/2025
BRC1 Extension
Principal Investigator
Role
Co-Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/04/2022 to 30/11/2022
Remodelling in Canine Myxomatous Mitral Valve Disease
Principal Investigator
Role
Co-Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/04/2022 to 31/03/2026
Remodelling in Myxomatous Mitral Valve Disease: The Relationship between Inflammation and the Development of Fibrosis
Principal Investigator
Role
Co-Investigator
Managing organisational unit
Bristol Medical School (THS)Dates
01/05/2021 to 30/04/2026
Thesis supervisions
Impact of baseline myocardial infarction in experimental and clinical cardiac surgery
Supervisors
Cardiac remodelling following myocardial infarction and the cardioprotective efficacy of adrenergic stimulation against reperfusion injury in healthy and failing hearts
Supervisors
Simultaneous Activation of PKA and Epac is Cardioprotective in Neonatal and Adult hearts
Supervisors
Cardiac Survival Signalling, Oxidative Stress & Reperfusion Injury during Postnatal Development
Supervisors
Development and characterisation of a porcine closed chest model of acute myocardial infarction for cells, drugs, and tissue engineering applications.
Supervisors
The Cardio-protective Efficacy of Cardioplegic Solution Supplemented with Sildenafil in Neonatal Pig Model of Cardiopulmonary Bypass and Cardioplegic Arrest
Supervisors
Post-translational modifications in mitochondrial dynamics
Supervisors
Mechanisms underlying the protective effects of cAMP in cardiac fibrosis
Supervisors
Decellularised Veins as a Scaffold for in situ Vascular Tissue Engineering
Supervisors
Characterisation of post ischaemic cardiac remodelling in rodent and porcine models of cardiac injury
Supervisors
Publications
Recent publications
01/05/2025Preoperative consecutive treatment with isoprenaline and adenosine is safe and reduces ischaemia-reperfusion injury in a porcine model of cardiac surgery with recent acute myocardial infarction
European Journal of Cardio-Thoracic Surgery
Proteomic Screening of Early Reperfusion in Acute Ischemic Heart and Insights into Mitochondrial-Associated Cell Damage
Frontiers in Bioscience-Landmark
Remodeling of the cardiac striatin interactome and its dynamics in the diabetic heart
Scientific Reports
Sympathetic reactivity to physiological stress is associated with expanded cardiac extracellular volume in humans
BMC Medicine
Corrigendum
Frontiers in Surgery
Related people
Dr Igor Khaliulin
Research Fellow
Bristol Medical School (THS)
Professor Gianni Angelini
BHF Professor of Cardiac Surgery and Director
Bristol Medical School (THS)
Professor Sarah George
Dean of the Faculty of Health Sciences
Life Sciences Faculty Office
Professor Massimo Caputo
Professor of Congenital Heart Surgery
Bristol Medical School (THS)
Professor Raimondo Ascione
Professor of Cardiac Surgery and Translational Research and Director of TBRC
Bristol Medical School (THS)